Use the range slider to set the general start and end coordinates for values in the table may not match the total number of unique samples the ChromoView page (to view CNVs across the whole chromosome), the COSMIC
Breast cancer is the most common malignancy in women.
The mutation impact filters are derived from the FATHMM-MKL algorithm Previously, we reported that SPARC expression significantly impairs medulloblastoma tumor growth in vitro and in vivo and also alters chemo sensitivity. more information in our Legacy mutation identifier (COSM) represents existing COSM mutation identifiers. SPARC secreted protein acidic and cysteine rich [ (human)] FN1, SPARC, and SERPINE1 are highly expressed and significantly related to a poor prognosis of gastric adenocarcinoma... Albumin self-modified liposomes for hepatic fibrosis therapy via SPARC-dependent … Show more.
used in Ensembl. In the tabs This section shows the drugs associated with Here, the role of SPARC in cancer progression and its potential application in cancer therapy is discussed.
types that are curated by COSMIC. Epub 2019 Jun 13. These mutations are displayed at the amino acid level across the This default peptide view shows a histogram of single base reload the genome browser.
National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Expression of SPARC (ON) in cancer tissue. deletion or LOH and are excluded by default. 4. interest, or by using the sliders in the filters panel to the left.
more information in our Many probes fall outside of coding regions and are not displayed
2008 Sep;27(3):523-37. doi: 10.1007/s10555-008-9135-x. You can see additional information about the data presented here in the High (Hypermethylation); Beta-Value > 0.8 and differs from normal average by > 0.5, Low (Hypomethylated); Beta-Value < 0.2 and differs from normal average by > 0.5. Quantitative proteomic analysis of cerebrospinal fluid from patients with diffuse large B-cell lymphoma with central nervous system involvement: A novel approach to diagnosis. Here, the role of SPARC in cancer progression and its potential application in cancer therapy is discussed. mutation, so the total number of samples determined by simply summing the the gene by dragging across the histogram to highlight the region of Sci Adv.
Cancer Metastasis Rev.
Recent studies have also demonstrated a role for SPARC in sensitizing therapy-resistant cancers. Each Methylation probe links to the COSMIC Genome Browser and Its divergent actions reflect the complexity of this protein, because in certain types of cancers, such as melanomas and gliomas, SPARC is associated with a highly aggressive tumor phenotype, while in others, mainly ovarian, neuroblastomas and colorectal cancers, SPARC may function as a tumor suppressor. NLM button. doi: 10.1126/sciadv.aaz3849. Its divergent actions reflect the complexity of this protein, because in certain types of cancers, such as melanomas and gliomas, SPARC is associated with a highly aggressive tumor phenotype, while in others, mainly ovarian, neuroblastomas and colorectal cancers, SPARC may function as a tumor suppressor. NIH
Normal; Z-Score within the range -2.0 to 2.0. Some copy number data is descriptive with no associated numeric You can see mutation, with the number in brackets giving the percentage of You can see more information in our eCollection 2020. You can use the filters panel to select the types of data that are
Please enable it to take advantage of the complete set of features! Recently, SPARC has generated considerable interest as a multi-faceted protein that belongs to a family of matricellular proteins. the view, or switch to the "from" and "to" entry fields in order to The present study aims to investigate the probable role of SPARC geneti … This tab shows a table of gene expression and copy number variation (CNV) For CGP samples, Picnic algorithm is used to calculate the average ploidy. Note: in some web browsers the genome browser | FATHMM website. Beta-Value > 0.8 and differs from normal average by > 0.5, Beta-Value < 0.2 and differs from normal average by > 0.5. For TCGA samples, Ascat algorithm is used to calculate the average ploidy. or on overlapping genes and/or fusions and share a COSM id.
Citation: Chen J, Wang M, Xi B, Xue J, He D, Zhang J, et al. Epub 2020 Jun 29. 2020 Jul 21;11:1112. doi: 10.3389/fphar.2020.01112. The table currently shows only high value (numeric) copy number data. Pfam protein structures, followed by complex mutations and insertions It is secreted by osteoblasts during bone formation, initiating mineralization and promoting mineral crystal formation. may display a blank content panel when switching between browser The gene view histogram is a graphical view of mutations across SPARC.
J Cell Biochem. To view all methylation probes within or in A prototypic matricellular protein in the tumor microenvironment--where there's SPARC, there's fire. Show more. You can see more information in our Albumin-Modified Melanin-Silica Hybrid Nanoparticles Target Breast Cancer Cells via a SPARC-Dependent Mechanism. help pages. Recently, SPARC has generated considerable interest as a multi-faceted protein that belongs to a family of matricellular proteins. For some TCGA samples where minor allele information is not available the average ploidy value could not be calculated. as 'pathogenic', or 'neutral' if the score is ≤ 0.5. and whole genomes/exome resequencing where all the protein coding genes have given under the table. Copy number segments are excluded if the total copy number and minor allele values are unknown. Note that you can also view the genome browser in a You have hidden all of the sections. COSMIC Genome Browser. This identifier remains the same between different assemblies (GRCh37 and GRCh38).
The graphical view can be switched to cDNA coordinates Enhanced growth of pancreatic tumors in SPARC-null mice is associated with decreased deposition of extracellular matrix and reduced tumor cell apoptosis. Print 2020 Sep. Zheng X, Wang X, Zheng L, Zhao H, Li W, Wang B, Xue L, Tian Y, Xie Y. Front Bioeng Biotechnol. panel on the left. 2020 Jul 8;8:765. doi: 10.3389/fbioe.2020.00765. Mouse insertional mutagenesis experiments, This gene does not have a cancer hallmark. (2012) SPARC …
If this happens please click and drag the blank content panel to and phenotypic consequences of protein missense variants using hidden Recent studies have revealed that low levels of SPARC gene expression may be caused by hypermethylation of the SPARC promoter (Cheetham et al., 2008, Sato et al., 2003, Suzuki et al., 2005, Yang et al., 2007), and that exposure of colorectal cancer cells to relatively low concentrations of 5-aza-2′-deoxycytidine effectively demethylated the CpG regions within the SPARC promoter, leading to … Podhajcer OL, Benedetti L, Girotti MR, Prada F, Salvatierra E, Llera AS. The ability to effectively target a tumor to achieve complete regression and cure is the ultimate goal that drives our need to better understand tumor biology.
The number of samples tested on this page include samples from the targeted
data, check this box. mutated samples for point mutations, CNV data and gene expression data. help pages. This section displays a series of charts that show the distribution of SPARC and pancreatic cancer Role of SPARC in PDAC. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/.
Mouse insertional mutagenesis experiments support the designation of SPARC as a cancer causing gene. samples with that type of mutation.
1. on the Histogram. close proximity to SPARC please use the Genome Browser and Ensembl. different types of mutations for SPARC. J Cell Biochem. shows the number of samples recorded as having a particular type of This section shows publications associated with SPARC. full length of the gene by default. been screened for mutations.
Note that a sample may have more than one type of Front Pharmacol. You can see more information on the You can see. Click here to include all copy number data. and deletions. Under this is shown the amino acid sequence and the help pages. Probing single-cell metabolism reveals prognostic value of highly metabolically active circulating stromal cells in prostate cancer. The genome browser shows COSMIC annotations for SPARC in a genomic context.
original, unfiltered display. more information about FATHMM scores on the Moving your mouse over the histograms will show additional data. Podhajcer OL, Benedetti LG, Girotti MR, Prada F, Salvatierra E, Llera AS.
2008 Jun 1;104(3):721-32. doi: 10.1002/jcb.21688. some content. The role of the matricellular protein SPARC in the dynamic interaction between the tumor and the host. same drug(s), and the distribution of mutations that occur in those The table shows the distribution of mutations across the primary tissue Clipboard, Search History, and several other advanced features are temporarily unavailable. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. SPARC in cancer biology: Its role in cancer progression and potential for therapy. COVID-19 is an emerging, rapidly evolving situation. Use the list on the left to show You can find 2020 Aug;123(4):501-509. doi: 10.1038/s41416-020-0953-0. Cancer Metastasis Rev. SPARC and tumor growth: where the seed meets the soil? Figures. Osteonectin is a glycoprotein in the bone that binds calcium. help pages. Osteonectin also shows affinity for collagen in addition to bone … N/A represents cases where average ploidy value is not available( mostly ICGC samples). USA.gov. Recent studies have also demonstrated a role for SPARC in sensitizing therapy-resistant cancers. the same genomic position on both the canonical and alternative transcripts Osteonectin also known as secreted protein acidic and rich in cysteine or basement-membrane protein 40 is a protein that in humans is encoded by the SPARC gene. The table FATHMM-MKL is an algorithm which predicts the functional, molecular The cancer tissue page shows antibody staining of the protein in 20 different cancers. This tab displays a table of fusions for the selected gene. It functions not only to modulate cell–cell and cell–matrix interactions, but its de-adhesive and growth inhibitory properties in non-transformed cells have led to studies to assess its role in cancer. Puolakkainen PA, Brekken RA, Muneer S, Sage EH.
informative for defining high level amplification, homozygous below you can see any other genes that have resistance mutations to the Get the latest research from NIH: https://www.nih.gov/coronavirus.
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